Adenosylcobalamin
Adenosylcobalamin (cobamamide, 5'-deoxyadenosylcobalamin) is a form of vitamin B12 with a 5'-deoxyadenosyl group bound to the central cobalt atom. It is made either by recovering it from bacterial fermentation without converting it to cyanocobalamin, or semi-synthetically from other cobalamins, then purified and crystallized. It is a dark red powder that is very sensitive to light, so it is handled under subdued light and sold as pure material and as diluted powders, often blended with methylcobalamin.
Suppliers sell different products under the same name. Specify the one you need.
High-purity adenosylcobalamin for premix makers and manufacturers who dilute it themselves.
Adenosylcobalamin on a carrier such as dicalcium phosphate or microcrystalline cellulose at 1%.
Pre-mixed cobalamin blends from some suppliers; check the stated amount of each form.
Compare each result with your own specification when the lot arrives.
Adenosylcobalamin breaks down rapidly in light, so keep it in light-proof, tightly sealed containers in a cool, dry place and handle it under subdued light. Suppliers set shelf life or a retest date, with HPLC assay and related cobalamins as the usual retest checks.
Record assay and hydroxocobalamin content for each lot, and dose from the actual assay. Keep pure material, dilutions and blends as separate items.
Facts from regulators and standards bodies, each linked to its source.
Health Canada's Multi-Vitamin/Mineral Supplements monograph lists cobamamide as a source ingredient for vitamin B12.
Source: webprod.hc-sc.gc.ca (opens in a new tab)21 CFR 101.9(c)(8)(iv) sets the Reference Daily Intake for vitamin B12 at 2.4 mcg for adults and children 4 years and older.
Source: ecfr.gov (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Nanjing, China
Nanjing-based maker and marketer of ingredients for food, nutrition, personal care and feed. Its food and nutrition range includes vitamin C and the main B vitamins in several forms.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include pure material, 1% trituration and blends with methylcobalamin. Ask each supplier for the specification sheet of the exact grade they quote.
Expect assay (HPLC), related cobalamins, identity, loss on drying or water, content uniformity (dilutions) and heavy metals and microbiology, each with its method, specification and result for that lot.
Adenosylcobalamin breaks down rapidly in light, so keep it in light-proof, tightly sealed containers in a cool, dry place and handle it under subdued light. Suppliers set shelf life or a retest date, with HPLC assay and related cobalamins as the usual retest checks.
Health Canada's Multi-Vitamin/Mineral Supplements monograph lists cobamamide as a source ingredient for vitamin B12. 21 CFR 101.9(c)(8)(iv) sets the Reference Daily Intake for vitamin B12 at 2.4 mcg for adults and children 4 years and older.
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