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Calcium gluconate

Calcium gluconate suppliers and sourcing guide

Calcium gluconate is the calcium salt of gluconic acid, produced by neutralizing gluconic acid with lime or calcium carbonate. Gluconic acid itself is made by fermenting glucose. The salt is a white, odorless crystalline powder, usually the monohydrate, and it carries only about 9% calcium, so it is chosen for taste and solubility rather than concentration. Brands buy it for beverages, liquid nutrition and as a firming agent and sequestrant in foods.

See suppliersWhat to ask for on the COA
Also known as
Calcium D-gluconate · Calcium gluconate monohydrate · E578
Facts checked
November 2026

Forms and grades of calcium gluconate

Suppliers sell different products under the same name. Specify the one you need.

  • Monohydrate powder

    The standard form, sold as fine or granular powder for dry blends and drinks.

  • Anhydrous

    Dried grade with slightly more calcium per gram, specified where water content matters.

  • Granular for tableting

    Agglomerated grades that flow on tablet presses, used in chewables and effervescent tablets.

  • Blends

    Combined with calcium lactate (calcium lactate gluconate) for higher solubility in clear drinks.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Assay
Calcium gluconate content on the dried basis by EDTA titration, against a Food Chemicals Codex or USP specification.
Loss on drying
Water content, confirming the monohydrate or anhydrous grade.
Reducing substances
A limit test for residual glucose and other reducing sugars from the fermentation step.
Chloride and sulfate
Limit tests for salts left from processing.
Lead and other metals
Lead and arsenic by ICP-MS.
Microbiology
Total plate count, yeast and mold for beverage and liquid uses.

Storage, lots and expiry

Storage and shelf life

Store calcium gluconate in tightly closed containers in a cool, dry place; it is stable but slowly soluble and can cake when damp. Keep it off the floor and away from odors. Shelf life is set by the supplier's specification, with retest of assay, moisture and micro on aged lots.

Lots and expiry dates

Record assay and loss on drying for each lot so calcium per serving is calculated correctly. If it is used in clear drinks, check solution clarity on each new lot, since dissolution can vary with particle size.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

  • 21 CFR 184.1199 affirms calcium gluconate as GRAS for use as a firming agent, formulation aid, sequestrant, stabilizer or thickener, and texturizer, with maximum levels set for several food categories.

    Source: ecfr.gov (opens in a new tab)

  • FDA's Substances Added to Food inventory lists calcium gluconate with technical effects including nutrient supplement and sequestrant, citing 21 CFR 184.1199.

    Source: hfpappexternal.fda.gov (opens in a new tab)

  • Health Canada's Multi-Vitamin/Mineral Supplements monograph for natural health products lists calcium gluconate and calcium gluconate monohydrate among the source ingredients for calcium (Table 2).

    Source: webprod.hc-sc.gc.ca (opens in a new tab)

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

Calcium gluconate suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking calcium gluconate suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

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Frequently asked questions

What forms of calcium gluconate can brands buy?

Common forms include monohydrate powder, anhydrous, granular for tableting and blends. Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for calcium gluconate include?

Expect assay, loss on drying, reducing substances, chloride and sulfate, lead and other metals and microbiology, each with its method, specification and result for that lot.

How should calcium gluconate be stored?

Store calcium gluconate in tightly closed containers in a cool, dry place; it is stable but slowly soluble and can cake when damp. Keep it off the floor and away from odors. Shelf life is set by the supplier's specification, with retest of assay, moisture and micro on aged lots.

What is the regulatory status of calcium gluconate?

21 CFR 184.1199 affirms calcium gluconate as GRAS for use as a firming agent, formulation aid, sequestrant, stabilizer or thickener, and texturizer, with maximum levels set for several food categories. FDA's Substances Added to Food inventory lists calcium gluconate with technical effects including nutrient supplement and sequestrant, citing 21 CFR 184.1199. Health Canada's Multi-Vitamin/Mineral Supplements monograph for natural health products lists calcium gluconate and calcium gluconate monohydrate among the source ingredients for calcium (Table 2).

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