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Carbamide peroxide

Carbamide peroxide suppliers and sourcing guide

Carbamide peroxide is a crystalline addition compound of urea and hydrogen peroxide in a 1:1 ratio, containing about 36% hydrogen peroxide by weight. It is made by crystallizing urea from concentrated hydrogen peroxide solution and drying the crystals at low temperature. Brands buy it as a white powder to make tooth whitening gels, often in anhydrous glycerin or glycol bases, and ear-care products.

See suppliersWhat to ask for on the COA
Also known as
Urea peroxide · Urea hydrogen peroxide · Percarbamide · CAS 124-43-6
Facts checked
November 2026

Forms and grades of carbamide peroxide

Suppliers sell different products under the same name. Specify the one you need.

  • Crystalline powder

    The standard form, sold by available hydrogen peroxide or carbamide peroxide assay.

  • Pharmacopeial grade

    Material made to a USP monograph, used where the finished product is a drug.

  • Pre-made gels

    Carbamide peroxide already dispersed in an anhydrous gel base at a stated percentage, for brands without in-house mixing.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Assay
Carbamide peroxide or available hydrogen peroxide by permanganate or iodometric titration.
Urea content
Urea by nitrogen determination or HPLC, confirming the 1:1 adduct.
Water
Water content, which speeds decomposition.
Heavy metals
Iron and other metals by ICP; trace metals speed peroxide breakdown.
Appearance and solubility
White crystals that dissolve clear in water; yellowing or residue suggests contamination.

Storage, lots and expiry

Storage and shelf life

Store carbamide peroxide sealed, cool (many suppliers specify refrigerated storage) and dry, away from metals, organics and reducing agents, since it slowly loses active oxygen. Do not return unused powder to the original container. Shelf life is set by the supplier, and assay should be retested before using older stock.

Lots and expiry dates

Record the actual peroxide assay for each lot and calculate batch weights from it, because potency drops with time and heat. Rotate strictly first in, first out and log storage temperature.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

  • Health Canada's Cosmetic Ingredient Hotlist covers urea (carbamide) peroxide under its peroxide and peroxide-generating compounds entry, which does not permit these compounds in products applied to the genital area and requires a study for oral cosmetics above 3% hydrogen peroxide or equivalent.

    Source: canada.ca (opens in a new tab)

  • 21 CFR 310.534 states that OTC oral products of this type, including carbamide peroxide in anhydrous glycerin, are regarded as new drugs that need an approved application.

    Source: ecfr.gov (opens in a new tab)

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

Carbamide peroxide suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking carbamide peroxide suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

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Frequently asked questions

What forms of carbamide peroxide can brands buy?

Common forms include crystalline powder, pharmacopeial grade and pre-made gels. Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for carbamide peroxide include?

Expect assay, urea content, water, heavy metals and appearance and solubility, each with its method, specification and result for that lot.

How should carbamide peroxide be stored?

Store carbamide peroxide sealed, cool (many suppliers specify refrigerated storage) and dry, away from metals, organics and reducing agents, since it slowly loses active oxygen. Do not return unused powder to the original container. Shelf life is set by the supplier, and assay should be retested before using older stock.

What is the regulatory status of carbamide peroxide?

Health Canada's Cosmetic Ingredient Hotlist covers urea (carbamide) peroxide under its peroxide and peroxide-generating compounds entry, which does not permit these compounds in products applied to the genital area and requires a study for oral cosmetics above 3% hydrogen peroxide or equivalent. 21 CFR 310.534 states that OTC oral products of this type, including carbamide peroxide in anhydrous glycerin, are regarded as new drugs that need an approved application.

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