Lactoperoxidase
Lactoperoxidase suppliers and sourcing guide
Lactoperoxidase is a peroxidase enzyme naturally present in cow's milk and whey. It is isolated from skim milk or whey by cation-exchange chromatography, then concentrated and freeze- or spray-dried to a powder. Buyers use it in the lactoperoxidase system, combined with thiocyanate and a hydrogen peroxide source, in some dairy products, oral-care products and cosmetics.
- Category
- Enzymes
- Also known as
- LPO · Milk peroxidase · Donor:hydrogen-peroxide oxidoreductase · EC 1.11.1.7 · CAS 9003-99-0
- Facts checked
- November 2026
Forms and grades of lactoperoxidase
Suppliers sell different products under the same name. Specify the one you need.
Purified powder
Lactoperoxidase isolated from bovine milk or whey, sold by activity per gram.
Lactoperoxidase system kits
Premixes of lactoperoxidase with sodium or potassium thiocyanate and glucose oxidase or another peroxide source.
Whey protein fractions
Whey protein ingredients that carry lactoperoxidase along with lactoferrin and other minor proteins.
What to check on the COA
Compare each result with your own specification when the lot arrives.
- Peroxidase activity
- Activity by oxidation of ABTS or guaiacol in the presence of hydrogen peroxide, in units per mg under stated conditions.
- Protein and purity
- Protein content by Kjeldahl or Dumas and purity by SDS-PAGE or HPLC.
- Identity and allergen
- Statement of bovine milk source and the milk allergen, which must be declared on finished labels.
- Loss on drying
- Moisture for powders by loss on drying; enzyme activity holds up better in dry product, so moisture above spec is a warning sign for activity loss in storage.
- Microbiology
- Total plate count, coliforms, E. coli and Salmonella, reported against the Food Chemicals Codex (FCC) general limits for enzyme preparations or the supplier's tighter specification.
Storage, lots and expiry
Storage and shelf life
Keep lactoperoxidase sealed in a cool, dry place, and refrigerate if the supplier specifies; activity drops with heat and moisture. Shelf life is set by the supplier's specification as a minimum activity to a date, and older stock is retested for activity before use.
Lots and expiry dates
Record measured activity and protein content for each lot, and the milk source and allergen statement. Rotate stock first-expired, first-out.
Regulatory status
Facts from regulators and standards bodies, each linked to its source.
Health Canada's Natural Health Products Ingredients Database lists lactoperoxidase (peroxidase) with Bos taurus milk as source material, and lists preservative and antimicrobial among its non-medicinal purposes.
Source: webprod.hc-sc.gc.ca (opens in a new tab)GRN 753, for sodium thiocyanate notified by Taradon Laboratory for use in the lactoperoxidase system in fresh cheese, frozen dairy desserts, fermented milk, flavored milk drinks and yogurt, closed with FDA having no questions.
Source: hfpappexternal.fda.gov (opens in a new tab)GRN 665, for the lactoperoxidase system itself (Taradon Laboratory), closed with FDA ceasing to evaluate the notice at the notifier's request.
Source: hfpappexternal.fda.gov (opens in a new tab)
This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Lactoperoxidase suppliers
Manufacturers and distributors whose own websites say they sell it.
We are checking lactoperoxidase suppliers now
Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.
Sell lactoperoxidase? Request a listingFrequently asked questions
What forms of lactoperoxidase can brands buy?
Common forms include purified powder, lactoperoxidase system kits and whey protein fractions. Ask each supplier for the specification sheet of the exact grade they quote.
What should the COA for lactoperoxidase include?
Expect peroxidase activity, protein and purity, identity and allergen, loss on drying and microbiology, each with its method, specification and result for that lot.
How should lactoperoxidase be stored?
Keep lactoperoxidase sealed in a cool, dry place, and refrigerate if the supplier specifies; activity drops with heat and moisture. Shelf life is set by the supplier's specification as a minimum activity to a date, and older stock is retested for activity before use.
What is the regulatory status of lactoperoxidase?
Health Canada's Natural Health Products Ingredients Database lists lactoperoxidase (peroxidase) with Bos taurus milk as source material, and lists preservative and antimicrobial among its non-medicinal purposes. GRN 753, for sodium thiocyanate notified by Taradon Laboratory for use in the lactoperoxidase system in fresh cheese, frozen dairy desserts, fermented milk, flavored milk drinks and yogurt, closed with FDA having no questions. GRN 665, for the lactoperoxidase system itself (Taradon Laboratory), closed with FDA ceasing to evaluate the notice at the notifier's request.
More enzymes
- PapainCarica papaya protease · Papaya latex enzyme
- BromelainPineapple protease · Stem bromelain
- Fungal proteaseAspergillus oryzae protease · Acid protease
- Alpha-amylaseα-Amylase · 1,4-α-D-glucan glucanohydrolase
- GlucoamylaseAmyloglucosidase · Glucan 1,4-α-glucosidase
- LactaseBeta-galactosidase · β-D-galactoside galactohydrolase
- LipaseTriacylglycerol lipase · EC 3.1.1.3
- CellulaseEndo-1,4-β-glucanase · EC 3.2.1.4
- XylanaseEndo-1,4-β-xylanase · EC 3.2.1.8
- PectinasePolygalacturonase · Pectin lyase
- InvertaseBeta-fructofuranosidase · Sucrase
- Alpha-galactosidaseα-Galactosidase · α-D-galactoside galactohydrolase
Sell ingredients to brands?
Request a free listing for the ingredients you make or distribute. No paid placement.