Skip to content
SupplyList
Menu

Sodium monofluorophosphate

Sodium monofluorophosphate suppliers and sourcing guide

Sodium monofluorophosphate is an inorganic salt (Na2PO3F) made by reacting sodium fluoride with sodium metaphosphate at high temperature, then cooling and milling the melt. It is a fluoride source used as the active ingredient in many toothpastes, where it is regulated as an over-the-counter drug in the US and through the oral health monograph in Canada rather than as a cosmetic ingredient. Brands buy it as a white, water-soluble powder of dental or pharmacopeial grade.

See suppliersWhat to ask for on the COA
Also known as
SMFP · MFP · Disodium phosphorofluoridate · Disodium fluorophosphate · CAS 10163-15-2
Facts checked
November 2026

Forms and grades of sodium monofluorophosphate

Suppliers sell different products under the same name. Specify the one you need.

  • USP grade

    Powder made to the pharmacopeial monograph, the usual choice for US over-the-counter toothpaste.

  • Dental or technical grade

    Grades made for oral care manufacturers, with specifications for total and free fluoride.

  • Fine powder

    Milled grades that dissolve quickly in toothpaste premixes.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Assay and total fluorine
Na2PO3F content and total fluorine, typically by ion chromatography or ion-selective electrode after hydrolysis.
Free fluoride
Fluoride ion not bound as monofluorophosphate, by ion-selective electrode, with a maximum set by the specification.
Loss on drying and pH
Moisture and the pH of a solution, which confirm handling and formulation behavior.
Heavy metals and arsenic
Lead, arsenic and other metals by ICP-MS.
Insoluble matter
Insoluble residue after dissolving, a sign of process or packaging contamination.

Storage, lots and expiry

Storage and shelf life

Store sodium monofluorophosphate tightly closed in a cool, dry, segregated area, away from acids, and treat it as a toxic substance when handling the powder. Moisture can slowly hydrolyze it to free fluoride, so keep containers sealed between uses. Shelf life and retest dates come from the supplier's specification.

Lots and expiry dates

Record the total and free fluoride results for every lot, since the finished toothpaste must hit a narrow fluoride range. Many brands also retest available fluoride in the finished product over its shelf life, because compatibility with the abrasive affects it.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

  • 21 CFR 355.10 lists sodium monofluorophosphate as an anticaries active ingredient, for example at 0.654 to 0.884 percent in gel or paste dentifrices containing 850 to 1,150 ppm theoretical total fluorine.

    Source: ecfr.gov (opens in a new tab)

  • Health Canada's Cosmetic Ingredient Hotlist lists fluoride-containing substances, including sodium monofluorophosphate, as not permitted in oral cosmetic products.

    Source: canada.ca (opens in a new tab)

  • Health Canada's Oral Health Products monograph lists sodium monofluorophosphate in dentifrices at 0.654 - 0.884% w/w, with 850 - 1150 mg/kg theoretical total fluoride and at least 800 mg/kg available fluoride ion.

    Source: webprod.hc-sc.gc.ca (opens in a new tab)

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

Sodium monofluorophosphate suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking sodium monofluorophosphate suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

Sell sodium monofluorophosphate? Request a listing

Frequently asked questions

What forms of sodium monofluorophosphate can brands buy?

Common forms include uSP grade, dental or technical grade and fine powder. Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for sodium monofluorophosphate include?

Expect assay and total fluorine, free fluoride, loss on drying and pH, heavy metals and arsenic and insoluble matter, each with its method, specification and result for that lot.

How should sodium monofluorophosphate be stored?

Store sodium monofluorophosphate tightly closed in a cool, dry, segregated area, away from acids, and treat it as a toxic substance when handling the powder. Moisture can slowly hydrolyze it to free fluoride, so keep containers sealed between uses. Shelf life and retest dates come from the supplier's specification.

What is the regulatory status of sodium monofluorophosphate?

21 CFR 355.10 lists sodium monofluorophosphate as an anticaries active ingredient, for example at 0.654 to 0.884 percent in gel or paste dentifrices containing 850 to 1,150 ppm theoretical total fluorine. Health Canada's Cosmetic Ingredient Hotlist lists fluoride-containing substances, including sodium monofluorophosphate, as not permitted in oral cosmetic products. Health Canada's Oral Health Products monograph lists sodium monofluorophosphate in dentifrices at 0.654 - 0.884% w/w, with 850 - 1150 mg/kg theoretical total fluoride and at least 800 mg/kg available fluoride ion.

More cosmetic bases, emollients and surfactants

All 76 cosmetic bases, emollients and surfactants

Sell ingredients to brands?

Request a free listing for the ingredients you make or distribute. No paid placement.

Request a listing