Heat-killed Lactobacillus (postbiotic)
Heat-killed Lactobacillus ingredients are lactic acid bacteria, mostly strains of species formerly in the Lactobacillus genus such as Lactiplantibacillus plantarum and Lacticaseibacillus paracasei, grown by fermentation, harvested and heat-treated so no cells stay viable before drying. They are sold by total cell count or by weight rather than CFU. Because nothing needs to stay alive, they go into hot-filled drinks, baked goods and other heat-processed foods, and both the strain and the heat process belong on the specification.
Suppliers sell different products under the same name. Specify the one you need.
Washed, inactivated cells of a named strain, dried and sold at a stated total cell count per gram.
Inactivated culture that keeps some or all of the fermentation medium and cell fragments, sold by weight.
Cell powder diluted with dextrin or another carrier to a fixed count for easier dosing.
A strain with its deposit number and documentation; inactivated strains are not interchangeable with each other.
Compare each result with your own specification when the lot arrives.
Heat-killed powders do not lose viability, so they are usually stored sealed at room temperature, cool and dry, away from humidity; follow the supplier's stated conditions. Keep containers closed between uses. Shelf life is set by the supplier's specification, typically from moisture and cell-count stability data.
Record the total cell count, strain and inactivation result for each lot, and keep it traceable to finished batches. Rotate stock FEFO.
Facts from regulators and standards bodies, each linked to its source.
Health Canada's Probiotics monograph excludes non-viable forms of its listed microorganisms, such as heat-killed or thermostabilised cells, from the monograph and its compendial application process.
Source: webprod.hc-sc.gc.ca (opens in a new tab)FDA's GRAS Notice Inventory lists GRN 324 for heat-killed Lactobacillus plantarum, notified by House Wellness Foods Corporation; at the notifier's request, FDA ceased to evaluate the notice.
Source: hfpappexternal.fda.gov (opens in a new tab)FDA's GRAS Notice Inventory lists GRN 1337 for heat-killed Lacticaseibacillus paracasei 327, notified by Kerry Ingredients and Flavors, with FDA's letter shown as pending.
Source: hfpappexternal.fda.gov (opens in a new tab)FDA's list of recently updated new dietary ingredient notifications it has reviewed includes NDIN 1443, heat-killed Lactiplantibacillus plantarum beLP1 from Bereum Co., Ltd.; the list does not state the content of FDA's response.
Source: fda.gov (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Lund, Sweden
Swedish developer and producer of proprietary probiotic strains, including Lactiplantibacillus plantarum 299v, sold to supplement and food brands as bulk ingredients or finished formats. It is part of the Symrise group.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include heat-killed cell powder, fermentate or lysate, diluted grades and named strain. Ask each supplier for the specification sheet of the exact grade they quote.
Expect total cell count, inactivation check, identity, contaminant microbiology, moisture and heavy metals, each with its method, specification and result for that lot.
Heat-killed powders do not lose viability, so they are usually stored sealed at room temperature, cool and dry, away from humidity; follow the supplier's stated conditions. Keep containers closed between uses. Shelf life is set by the supplier's specification, typically from moisture and cell-count stability data.
Health Canada's Probiotics monograph excludes non-viable forms of its listed microorganisms, such as heat-killed or thermostabilised cells, from the monograph and its compendial application process. FDA's GRAS Notice Inventory lists GRN 324 for heat-killed Lactobacillus plantarum, notified by House Wellness Foods Corporation; at the notifier's request, FDA ceased to evaluate the notice. FDA's GRAS Notice Inventory lists GRN 1337 for heat-killed Lacticaseibacillus paracasei 327, notified by Kerry Ingredients and Flavors, with FDA's letter shown as pending. FDA's list of recently updated new dietary ingredient notifications it has reviewed includes NDIN 1443, heat-killed Lactiplantibacillus plantarum beLP1 from Bereum Co., Ltd.; the list does not state the content of FDA's response.
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