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Gamma-cyclodextrin

Gamma-cyclodextrin suppliers and sourcing guide

Gamma-cyclodextrin is a ring of eight glucose units made from starch with a cyclodextrin glycosyltransferase enzyme, then purified, crystallized and dried. Its cavity is larger than those of alpha- and beta-cyclodextrin, and it is far more soluble in water than beta-cyclodextrin. It is sold as a white crystalline powder and used to form inclusion complexes with flavors, oils, fat-soluble vitamins and other compounds so they are easier to handle, disperse in water or keep stable.

See suppliersWhat to ask for on the COA
Also known as
γ-Cyclodextrin · Cyclooctaamylose · E458 · CAS 17465-86-0
Facts checked
November 2026

Forms and grades of gamma-cyclodextrin

Suppliers sell different products under the same name. Specify the one you need.

  • Food grade

    Crystalline powder for use as a carrier, stabilizer and formulation aid in foods.

  • Pharmaceutical grade

    Grades meeting the Ph. Eur. or USP/NF monograph for excipient use.

  • Pre-formed complexes

    Ready-made complexes of gamma-cyclodextrin with ingredients such as coenzyme Q10, curcumin or flavors, sold as powders with a stated active content.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Identity
HPLC retention time or IR compared with a reference standard.
Assay and related cyclodextrins
Gamma-cyclodextrin by HPLC, with alpha- and beta-cyclodextrin and other related substances reported.
Water
Water by Karl Fischer or loss on drying against the grade limit.
Reducing sugars and residual solvents
Reducing sugars by a colorimetric or titration method, and residual solvents or complexing agents by GC where the process uses them.
Heavy metals
Lead, arsenic, cadmium and mercury by ICP-MS against the supplier specification or the buyer's own limits.
Microbiology
Total plate count, yeast and mold, coliforms or E. coli, and Salmonella, which matter most when the ingredient goes uncooked into powders, capsules or tablets.

Storage, lots and expiry

Storage and shelf life

Store in closed containers in a cool, dry place away from strong odors. It is stable when dry; shelf life or retest date is set by the supplier, and older stock is retested for water and assay.

Lots and expiry dates

Water content varies by lot and changes the dry-basis amount in each kilogram. For pre-formed complexes, record the stated active content per lot, since it sets the dose in finished products.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

Gamma-cyclodextrin suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking gamma-cyclodextrin suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

Sell gamma-cyclodextrin? Request a listing

Frequently asked questions

What forms of gamma-cyclodextrin can brands buy?

Common forms include food grade, pharmaceutical grade and pre-formed complexes. Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for gamma-cyclodextrin include?

Expect identity, assay and related cyclodextrins, water, reducing sugars and residual solvents, heavy metals and microbiology, each with its method, specification and result for that lot.

How should gamma-cyclodextrin be stored?

Store in closed containers in a cool, dry place away from strong odors. It is stable when dry; shelf life or retest date is set by the supplier, and older stock is retested for water and assay.

What is the regulatory status of gamma-cyclodextrin?

GRN 46 (gamma-cyclodextrin, notified by Wacker Biochem Corp. for use as a stabilizer, emulsifier, carrier and formulation aid in listed foods) closed on Sep 22, 2000 with FDA having no questions. Health Canada's Natural Health Products Ingredients Database lists gamma-cyclodextrin with non-medicinal purposes of emulsifying agent, encapsulating agent, sequestering agent and stabilizing agent.

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