Hesperidin
Hesperidin suppliers and sourcing guide
Hesperidin is a flavanone glycoside, hesperetin bound to rutinose, and the main flavonoid in sweet orange peel. It is extracted from the peel or immature fruit of sweet and bitter orange, often by alkaline extraction followed by acid precipitation and purification, giving an off-white to pale yellow powder that dissolves poorly in water. Brands buy purified hesperidin, orange extracts standardized to hesperidin, or modified forms made for solubility.
- Category
- Specialty nutrients
- Also known as
- Hesperetin 7-rutinoside · Hesperetin 7-rhamnoglucoside · Citrus flavanone glycoside
- Facts checked
- November 2026
Forms and grades of hesperidin
Suppliers sell different products under the same name. Specify the one you need.
Purified hesperidin
Hesperidin at 90% or higher purity from orange peel, the standard grade for capsules and tablets.
Standardized orange extract
Orange extract with a declared hesperidin percentage, sometimes carrying other citrus flavonoids.
Micronized hesperidin
Hesperidin milled to a small particle size, used to make it easier to disperse.
Glucosyl hesperidin
Hesperidin modified with glucose by enzyme treatment, which dissolves readily in water for drinks.
Methyl hesperidin
A methylated, more water-soluble derivative used mainly in foods and cosmetics in some markets.
What to check on the COA
Compare each result with your own specification when the lot arrives.
- Assay (HPLC)
- Hesperidin content by HPLC against a reference standard, on an anhydrous or as-is basis.
- Related flavonoids
- Other citrus flavonoids such as narirutin and neohesperidin by HPLC, which show source and purity.
- Loss on drying
- Moisture, which affects the assay basis.
- Particle size
- For micronized grades, particle size distribution by laser diffraction.
- Heavy metals and pesticides
- Lead, arsenic, cadmium and mercury by ICP-MS, and a pesticide screen, since citrus peel can carry residues.
- Microbiology
- Total plate count, yeast and mold, and pathogens.
Storage, lots and expiry
Storage and shelf life
Keep hesperidin sealed in a cool, dry place away from light. The powder can dust and cake if humid, so reseal opened containers. Shelf life and retest dates are set by the supplier's specification.
Lots and expiry dates
Record the hesperidin assay and moisture for each lot, and for standardized extracts the actual percentage, which sets the dose per serving. Track citrus source (sweet or bitter orange) if it is on your specification.
Regulatory status
Facts from regulators and standards bodies, each linked to its source.
FDA's Substances Added to Food inventory lists hesperidin with the technical effect 'flavor enhancer'.
Source: hfpappexternal.fda.gov (opens in a new tab)GRN 796, for orange extract (85% hesperidin) from Ferrer HealthTech, closed in February 2019 with FDA having no questions.
Source: hfpappexternal.fda.gov (opens in a new tab)GRN 901, for glucosyl hesperidin from Hayashibara Co., closed in November 2020 with FDA having no questions.
Source: hfpappexternal.fda.gov (opens in a new tab)
This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Hesperidin suppliers
Manufacturers and distributors whose own websites say they sell it.
We are checking hesperidin suppliers now
Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.
Sell hesperidin? Request a listingFrequently asked questions
What forms of hesperidin can brands buy?
Common forms include purified hesperidin, standardized orange extract, micronized hesperidin, glucosyl hesperidin and methyl hesperidin. Ask each supplier for the specification sheet of the exact grade they quote.
What should the COA for hesperidin include?
Expect assay (HPLC), related flavonoids, loss on drying, particle size, heavy metals and pesticides and microbiology, each with its method, specification and result for that lot.
How should hesperidin be stored?
Keep hesperidin sealed in a cool, dry place away from light. The powder can dust and cake if humid, so reseal opened containers. Shelf life and retest dates are set by the supplier's specification.
What is the regulatory status of hesperidin?
FDA's Substances Added to Food inventory lists hesperidin with the technical effect 'flavor enhancer'. GRN 796, for orange extract (85% hesperidin) from Ferrer HealthTech, closed in February 2019 with FDA having no questions. GRN 901, for glucosyl hesperidin from Hayashibara Co., closed in November 2020 with FDA having no questions.
More specialty nutrients
- Coenzyme Q10 (ubiquinone)CoQ10 · Ubidecarenone
- UbiquinolReduced coenzyme Q10 · Ubiquinol-10
- Alpha-lipoic acidThioctic acid · ALA
- NMN (nicotinamide mononucleotide)Beta-nicotinamide mononucleotide · β-NMN
- Nicotinamide ribosideNR · Nicotinamide riboside chloride
- PQQPyrroloquinoline quinone · PQQ disodium salt
- Resveratroltrans-Resveratrol · 3,4',5-Trihydroxystilbene
- Quercetin3,3',4',5,7-Pentahydroxyflavone · Quercetin dihydrate
- RutinRutoside · Quercetin-3-rutinoside
- DiosminDiosmetin 7-rutinoside · Barosmin
- Citrus bioflavonoidsCitrus flavonoids · Bioflavonoid complex
- Pterostilbenetrans-Pterostilbene · 3,5-Dimethoxy-4'-hydroxystilbene
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