Citicoline
Citicoline is cytidine 5'-diphosphocholine (CDP-choline), a nucleotide made of cytidine, two phosphate groups and choline. Commercial citicoline is produced by microbial fermentation or an enzymatic process from precursors such as cytidine monophosphate or orotic acid and choline chloride, then purified and crystallized. Most supplement-grade material is the sodium salt, a white crystalline powder.
Suppliers sell different products under the same name. Specify the one you need.
The common supplement form, a crystalline sodium salt; label amounts are usually given as citicoline.
The non-salt form, offered by fewer suppliers.
Branded ingredients from specific manufacturers with their own specifications.
Granulated powder for better flow in tableting.
Compare each result with your own specification when the lot arrives.
Store in tightly sealed containers in a cool, dry place away from light; citicoline sodium is hygroscopic. Reseal opened containers promptly. Shelf life and retest date come from the supplier's specification.
Check that each lot's assay basis (as citicoline or as citicoline sodium, dried or as-is) matches how your label is calculated. Record moisture at receipt and rotate first-expiry-first-out.
Facts from regulators and standards bodies, each linked to its source.
A Health Canada multi-ingredient natural health product monograph lists citicoline (cytidine 5'-diphosphocholine) as a medicinal ingredient, with citicoline and citicoline sodium as source ingredients.
Source: webprod.hc-sc.gc.ca (opens in a new tab)The same monograph gives a citicoline dose of 250 to 1,000 milligrams per day, not to exceed 500 milligrams per single dose, for one of its listed uses.
Source: webprod.hc-sc.gc.ca (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · New York, NY
Sells it as Cognizin
North American sales office of Kyowa Hakko Bio, a Japanese fermentation company. It sells branded glutathione and citicoline plus pyridoxal-5'-phosphate and vitamin K2 (MK-4) to supplement and food makers.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include citicoline sodium, free acid (citicoline), branded fermentation-made citicoline and granular grades. Ask each supplier for the specification sheet of the exact grade they quote.
Expect assay (HPLC), identity, sodium content and pH, loss on drying, heavy metals and microbiology, each with its method, specification and result for that lot.
Store in tightly sealed containers in a cool, dry place away from light; citicoline sodium is hygroscopic. Reseal opened containers promptly. Shelf life and retest date come from the supplier's specification.
A Health Canada multi-ingredient natural health product monograph lists citicoline (cytidine 5'-diphosphocholine) as a medicinal ingredient, with citicoline and citicoline sodium as source ingredients. The same monograph gives a citicoline dose of 250 to 1,000 milligrams per day, not to exceed 500 milligrams per single dose, for one of its listed uses.
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