Glucosamine hydrochloride
Glucosamine hydrochloride is the hydrochloride salt of glucosamine, an amino sugar. It is made by hydrolyzing chitin from crustacean shells with hydrochloric acid, or by fungal or microbial fermentation for shellfish-free grades, then purifying and crystallizing the salt. It is a stable, white crystalline powder with a higher glucosamine content per gram than the stabilized sulfate salts, and is bought as powder or granules for tablets, capsules and drink mixes.
Suppliers sell different products under the same name. Specify the one you need.
Crystallized from crustacean chitin; finished products generally need a shellfish allergen statement.
Produced by fungal or microbial fermentation, used for vegetarian and shellfish-free products, with source documentation.
Granulated material with better flow for high-speed tableting.
Milled grades for capsules, powders and drink mixes where fast dissolution matters.
Compare each result with your own specification when the lot arrives.
Store in sealed containers in a cool, dry place away from direct light. The salt is more stable than glucosamine sulfate but still picks up moisture once opened. The supplier's specification sets the shelf life or retest date.
Keep the source (shellfish or fermentation) on the lot record along with the supplier's allergen statement, since it drives labeling. Check assay and loss on drying on each COA and rotate stock first-expiry-first-out.
Facts from regulators and standards bodies, each linked to its source.
Health Canada's Joint Health Products monograph lists glucosamine hydrochloride (glucosamine HCl), with crustacean exoskeleton among its source materials.
Source: webprod.hc-sc.gc.ca (opens in a new tab)GRN 150, for glucosamine hydrochloride prepared from Aspergillus niger chitin and notified by Cargill, Inc., closed in September 2004 when FDA ceased to evaluate it at the notifier's request.
Source: hfpappexternal.fda.gov (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Esplugues de Llobregat, Spain
Spanish life sciences company that produces heparin and joint-health ingredients from animal co-products. For supplement makers it offers native type II collagen, chondroitin sulfate, glucosamine and a hyaluronic acid matrix.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include shellfish-derived, fermentation-derived (non-shellfish), granular or direct-compression grades and fine powder. Ask each supplier for the specification sheet of the exact grade they quote.
Expect assay (HPLC or titration), identity, loss on drying and residue on ignition, pH, heavy metals and microbiology, each with its method, specification and result for that lot.
Store in sealed containers in a cool, dry place away from direct light. The salt is more stable than glucosamine sulfate but still picks up moisture once opened. The supplier's specification sets the shelf life or retest date.
Health Canada's Joint Health Products monograph lists glucosamine hydrochloride (glucosamine HCl), with crustacean exoskeleton among its source materials. GRN 150, for glucosamine hydrochloride prepared from Aspergillus niger chitin and notified by Cargill, Inc., closed in September 2004 when FDA ceased to evaluate it at the notifier's request.
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