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Grape seed extract

Grape seed extract suppliers and sourcing guide

Grape seed extract is made from the seeds of wine and juice grapes (Vitis vinifera), recovered from pomace in France, Italy, the US and China. The seeds are extracted with water or water-ethanol, purified and spray-dried to a reddish-brown powder rich in proanthocyanidins (oligomeric procyanidins, often called OPC). Products are sold on percent proanthocyanidins or polyphenols, and the assay method drives the number.

See suppliersWhat to ask for on the COA
Also known as
Vitis vinifera seed extract · grape seed proanthocyanidins · OPC · grape seed polyphenols
Facts checked
November 2026

Forms and grades of grape seed extract

Suppliers sell different products under the same name. Specify the one you need.

  • High-OPC extract

    Purified extract sold at roughly 90 to 95% proanthocyanidins by UV, used in capsules and tablets.

  • Polyphenol-standardized extract

    Extract sold on total polyphenols by Folin-Ciocalteu, sometimes with a monomer and oligomer breakdown by HPLC.

  • Water-extracted extract

    Extract made with water only, preferred by some buyers for food and beverage use.

  • Grape seed flour

    Defatted, milled seeds left after oil pressing, sold as a food ingredient.

What to check on the COA

Compare each result with your own specification when the lot arrives.

Proanthocyanidins assay
Proanthocyanidins by UV (acid-butanol or similar) or by HPLC; results differ a lot by method, so the method must be named.
Identity and adulteration (HPLC)
Monomer, dimer and oligomer profile; grape seed has mainly B-type procyanidins, which helps detect peanut skin or pine bark blending.
Residual solvents
Ethanol or other process solvents against USP <467>.
Heavy metals
Lead, arsenic, cadmium and mercury by ICP-MS.
Microbiology
Total plate count, yeast and mold, E. coli and Salmonella.
Loss on drying
Moisture of the spray-dried powder.

Storage, lots and expiry

Storage and shelf life

Keep the extract sealed in lined drums, cool, dry and away from light; it is hygroscopic and darkens with moisture and heat. Reseal opened containers. Shelf life or retest date comes from the supplier.

Lots and expiry dates

Proanthocyanidin numbers vary by method and by grape variety and seed source. Record the assay method, solvent and supplier lot for every lot.

Regulatory status

Facts from regulators and standards bodies, each linked to its source.

  • Health Canada's natural health product monograph for grape seed extract lists the seed of Vitis vinifera as the source material and covers dry extracts standardized to stated ranges of oligomeric proanthocyanidins (OPC).

    Source: webprod.hc-sc.gc.ca (opens in a new tab)

  • The EU Novel Food status Catalogue (entry POL-NF-00782) lists grape seed extract with 65% up to 95% OPC from Vitis vinifera as not novel in food supplements.

    Source: ec.europa.eu (opens in a new tab)

  • GRN 124 (grape seed extract, notified by San Joaquin Valley Concentrates for use in beverages, cereals, fats and oils, dairy, grain and fruit products at 0.01 to 0.08 percent) closed in Aug 2003 with FDA having no questions.

    Source: hfpappexternal.fda.gov (opens in a new tab)

This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.

Grape seed extract suppliers

Manufacturers and distributors whose own websites say they sell it.

We are checking grape seed extract suppliers now

Every listing is checked against the supplier’s own website before it goes live, so this list fills in over the coming weeks. The specs and COA checklist above are ready today.

Sell grape seed extract? Request a listing

Frequently asked questions

What forms of grape seed extract can brands buy?

Common forms include high-OPC extract, polyphenol-standardized extract, water-extracted extract and grape seed flour. Ask each supplier for the specification sheet of the exact grade they quote.

What should the COA for grape seed extract include?

Expect proanthocyanidins assay, identity and adulteration (HPLC), residual solvents, heavy metals, microbiology and loss on drying, each with its method, specification and result for that lot.

How should grape seed extract be stored?

Keep the extract sealed in lined drums, cool, dry and away from light; it is hygroscopic and darkens with moisture and heat. Reseal opened containers. Shelf life or retest date comes from the supplier.

What is the regulatory status of grape seed extract?

Health Canada's natural health product monograph for grape seed extract lists the seed of Vitis vinifera as the source material and covers dry extracts standardized to stated ranges of oligomeric proanthocyanidins (OPC). The EU Novel Food status Catalogue (entry POL-NF-00782) lists grape seed extract with 65% up to 95% OPC from Vitis vinifera as not novel in food supplements. GRN 124 (grape seed extract, notified by San Joaquin Valley Concentrates for use in beverages, cereals, fats and oils, dairy, grain and fruit products at 0.01 to 0.08 percent) closed in Aug 2003 with FDA having no questions.

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