Hydroxytyrosol
Hydroxytyrosol is a phenolic compound found in olives, olive leaves and olive oil, and in the water and pulp left after olive oil milling. Ingredients are either olive extracts, made from fruit, pulp, mill water or leaves and standardized to a hydroxytyrosol percentage, or high-purity hydroxytyrosol made by chemical synthesis or by purifying olive extracts. Brands buy powders, liquids and purified grades depending on the dose and format.
Suppliers sell different products under the same name. Specify the one you need.
Powder from olive fruit or pulp with a stated hydroxytyrosol percentage.
Liquid or dried extracts of olive mill water, specified by hydroxytyrosol content.
High-purity material from synthesis or extract purification.
Leaf extract that contains hydroxytyrosol alongside oleuropein.
Compare each result with your own specification when the lot arrives.
Store sealed, cool and protected from light and air; hydroxytyrosol oxidizes and darkens. Liquid concentrates may need refrigeration. Shelf life and retest date come from the supplier, with assay repeated at retest.
Record hydroxytyrosol content, source (olive fruit, leaf, mill water or synthetic) and color for each lot, and recalculate batch amounts for standardized extracts. Rotate first-expiry-first-out.
Facts from regulators and standards bodies, each linked to its source.
FDA's GRAS Notice Inventory lists GRN 600 for hydroxytyrosol, notified by Seprox Biotech S.L.; it closed on May 13, 2016 with FDA having no questions.
Source: hfpappexternal.fda.gov (opens in a new tab)GRN 876 (hydroxytyrosol, Nova Mentis Ltd) closed on January 21, 2020, and GRN 1182 (hydroxytyrosol, Hangzhou Viablife Biotech) closed on February 12, 2025, both with FDA having no questions.
Source: hfpappexternal.fda.gov (opens in a new tab)Health Canada's Natural Health Products Ingredients Database lists olive (Olea europaea) fruit, fruit flesh and leaf as source materials for hydroxytyrosol.
Source: webprod.hc-sc.gc.ca (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Rancho Santa Margarita, CA
California ingredient company that makes nature-identical specialty nutrients by fermentation and bioconversion, including ergothioneine, L-theanine, hydroxytyrosol, pterostilbene and vitamin K2.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include standardized olive fruit extract, olive vegetation water concentrates, purified or synthetic hydroxytyrosol and olive leaf extract. Ask each supplier for the specification sheet of the exact grade they quote.
Expect assay (HPLC), identity, residual solvents, pesticide residues, heavy metals and microbiology, each with its method, specification and result for that lot.
Store sealed, cool and protected from light and air; hydroxytyrosol oxidizes and darkens. Liquid concentrates may need refrigeration. Shelf life and retest date come from the supplier, with assay repeated at retest.
FDA's GRAS Notice Inventory lists GRN 600 for hydroxytyrosol, notified by Seprox Biotech S.L.; it closed on May 13, 2016 with FDA having no questions. GRN 876 (hydroxytyrosol, Nova Mentis Ltd) closed on January 21, 2020, and GRN 1182 (hydroxytyrosol, Hangzhou Viablife Biotech) closed on February 12, 2025, both with FDA having no questions. Health Canada's Natural Health Products Ingredients Database lists olive (Olea europaea) fruit, fruit flesh and leaf as source materials for hydroxytyrosol.
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