L-serine
L-serine is a non-essential amino acid with a hydroxyl side chain. Commercial L-serine is made by fermentation or by enzymatic conversion of glycine, then purified and crystallized. It is a white crystalline powder, readily soluble in water, that brands buy for amino acid blends, capsules and powders; it is also used as a raw material in cosmetics and cell culture media.
Suppliers sell different products under the same name. Specify the one you need.
Standard fine crystalline powder for capsules, tablets and dry blends.
L-serine tested to the USP monograph, used where a compendial grade is required for supplements.
L-serine tested to a Food Chemicals Codex or supplier food specification for use in foods and drink mixes.
L-serine sold for skin and hair products, tested to a cosmetic specification rather than a food or compendial one.
Compare each result with your own specification when the lot arrives.
Store L-serine in tightly closed, lined containers in a cool, dry place away from light and strong odors, and reseal opened packs promptly. Shelf life or retest date is set by the supplier's specification; assay, loss on drying and micro are the usual retest points for older stock.
Record assay and grade for each lot. Rotate stock FEFO.
Facts from regulators and standards bodies, each linked to its source.
21 CFR 172.320 lists L-serine among the amino acids that may be safely used as nutrients added to foods.
Source: ecfr.gov (opens in a new tab)Under 21 CFR 172.320, added plus naturally present L-serine may not exceed 8.4 percent by weight of the total protein of the finished food.
Source: ecfr.gov (opens in a new tab)FDA's Substances Added to Food inventory lists L-serine with the technical effects flavor enhancer, flavoring agent or adjuvant, and nutrient supplement.
Source: hfpappexternal.fda.gov (opens in a new tab)Health Canada's Workout Supplements monograph lists L-serine among its non-essential amino acids, with a dose range of 175.5 mg to 351 mg per day.
Source: webprod.hc-sc.gc.ca (opens in a new tab)This is general information, not regulatory advice. Status differs by country and by how the ingredient is used, so check the rules for your product and market.
Manufacturers and distributors whose own websites say they sell it.
Manufacturer · Raleigh, NC
North American subsidiary of the Ajinomoto Group. It supplies pharmaceutical- and food-grade amino acids made by fermentation, in pack sizes from R&D pails to bulk, plus custom amino acid blends.
Suppliers are in alphabetical order and none pays to appear. Each claim is checked against the supplier’s own website on the date shown. Ask for the specification sheet and a recent COA before you order, and confirm details with the supplier.
Common forms include crystalline, uSP grade, food grade and cosmetic grade. Ask each supplier for the specification sheet of the exact grade they quote.
Expect identity, assay, related substances, loss on drying and residue on ignition and heavy metals and microbiology, each with its method, specification and result for that lot.
Store L-serine in tightly closed, lined containers in a cool, dry place away from light and strong odors, and reseal opened packs promptly. Shelf life or retest date is set by the supplier's specification; assay, loss on drying and micro are the usual retest points for older stock.
21 CFR 172.320 lists L-serine among the amino acids that may be safely used as nutrients added to foods. Under 21 CFR 172.320, added plus naturally present L-serine may not exceed 8.4 percent by weight of the total protein of the finished food. FDA's Substances Added to Food inventory lists L-serine with the technical effects flavor enhancer, flavoring agent or adjuvant, and nutrient supplement. Health Canada's Workout Supplements monograph lists L-serine among its non-essential amino acids, with a dose range of 175.5 mg to 351 mg per day.
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